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Two-stage analysis based on a mixed model: Large sample asymptotic theory and small-sample simulation results.
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A method of exponential curve fitting by numerical integration. 1: Unconstrained Optimization. John Wiley & Sons, New York.įoss (1970). Approximate f-tests of multiple degree of freedom hypotheses in generalized least squares analysis of unbalanced split-plot experiments. John Wiley & Sons, NY.įai and Cornelius (1996). Simultaneous analysis of families of sigmoidal curves: Application to bioassay, radioligand assay and physiological dose-response curves. Academic Press, New York.ĭeLean, Munson and Rodbard (1978). Chapter 12 in Numerical Methods for Non-linear Optimization. A modified form of Levenberg's correction. A method for fitting linear combinations of exponentials. Restricted maximum likelihood (REML) estimation of variance components in the mixed models, Technometrics, 18:31–8.Ĭornell (1962). John Wiley & Sons, New York.Ĭorbeil and Searle (1976). Parameter Estimation in Engineering and Science. John Wiley & Sons, New York.īelsley, Kuh and Welsch (1980). Nonlinear Regression Analyses and Its Applications. John Wiley & Sons, New York.īeck and Arnold (1977). Academic Press, New York.īates and Watts (1988). Lifetime Learning Publications, Belmont, CA.īard (1974). Analyzing Experimental Data By Regression. Annals of the Institute of Mathematical Statistics 30:A9–14.Īllen and Cady (1982). Posterior probabilities for choosing a regression model. Drug Intelligence, Illinois.Īkaike (1978). Fundamentals of Clinical Pharmacokinetics. Kinetics of pharmacologic effects in man: The anticoagulant action of warfarin. Computational problems of compartmental models with Michaelis-Menten-type elimination. A semicompartmental modeling approach for pharmacodynamic data assessment. Direct linear plotting method for estimation of pharmacokinetic parameters. Corticosteroid pharmacodynamics: models for a broad array of receptor-mediated pharmacologic effects. Pharmacokinetics: Statistical moment calculations. Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, 5 th ed. Kinetic Data Analysis: Design and Analysis of Enzyme and Pharmacokinetic Experiments. J Pharmacokin Biopharm 21:457.Įndrenyi, ed. Comparison of four basic models of indirect pharmacodynamic responses.
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Noncompartmental determination of mean residence time and steady-state volume of distribution during multiple dosing, J Pharm Sci 80:202.ĭayneka, Garg and Jusko (1993). Estimation of statistical moments and steady-state volume of distribution for a drug given by intravenous infusion. ESTRIP, A BASIC computer program for obtaining initial polyexponential parameter estimates. Conditional Weighted Residuals (CWRES): A Model Diagnostic for the FOCE Method, Pharmaceutical Research, DOI:10.1007/s1109-x.īrown and Manno (1978). Additional references are provided below. References for the WinNonlin operational objects are provided in their descriptions.